Internal Medicine

🔍 The General Examination (Part 2)

High-Yield Clinical Examination

Clinical Skills

Continuing our systematic approach, Part 2 explores the oral cavity, skin manifestations, endocrine findings, and lymphatic system. The general examination connects physical signs across systems to form coherent clinical hypotheses.

👄 The Mouth: More Than Just Teeth

👄 Oral Cavity Assessment

Lip Examination:

🎯 Angular Cheilitis (Stomatitis)

  • Cracks/fissures at mouth corners
  • Associations: Iron deficiency, B-vitamin deficiency
  • Nutritional status indicator

Gum Assessment:

🎯 Gum Hypertrophy

  • Gingival overgrowth
  • Classic cause: Phenytoin (anti-seizure medication)

🎯 Spongy & Bleeding Gums

  • Diagnosis: Vitamin C deficiency (Scurvy)
  • Tender, hemorrhagic gingiva

🎯 Burton's Line

  • Blue-grey gum line
  • Cause: Chronic lead poisoning

Tongue Examination:

🎯 Glossitis

  • Smooth, beefy red appearance
  • Loss of papillae
  • Causes: Iron, B12, or Folate deficiency

🎯 Fasciculations

  • Fine, worm-like muscle twitches
  • Significance: Lower Motor Neuron disease (e.g., ALS)

🎯 Tongue Deviation

  • Protrusion deviation toward affected side
  • Indicates: CN XII (Hypoglossal) nerve lesion

🎯 Central Cyanosis

  • Most reliable site: Undersurface of tongue
  • Blue discoloration from hypoxemia

Buccal Mucosa & Oral Pathology:

🎯 Koplik's Spots

  • Tiny white spots on red background
  • Pathognomonic for: Measles

🎯 Buccal Pigmentation

  • Brown mucosal spots
  • Association: Addison's disease

🎯 Oral Thrush

  • White, cottage-cheese-like patches
  • Adherent plaques (cannot wipe away)
  • Causes: Candida infection in immunocompromised, infants, antibiotic/steroid use

🦠 The Skin: A Canvas of Internal Disease

🦠 Dermatological Manifestations

Examination Sequence:

🎯 Step 1: Inspection

  • Visual assessment of entire skin surface
  • Color, texture, lesions, distribution

🎯 Step 2: Palpation

  • Texture, temperature, moisture
  • Lesion consistency and mobility

Key History for Skin Lesions:

🎯 Onset & Progression

  • "Where did it start?"
  • "How has it spread?"

🎯 Symptom Assessment

  • "Does it itch?" (Pruritus)
  • Systemic causes: Lymphoma, liver disease, polycythemia

🎯 Treatment History

  • "What have you put on it?"
  • Topical treatments alter appearance

Key Dermatological Signs:

🎯 Acanthosis Nigricans

  • Velvety, dark pigmentation in body folds
  • Axillae, neck, groin involvement
  • Marker for: Internal malignancy (especially gastric cancer)

🎯 Pyoderma Gangrenosum

  • Rapidly progressing, painful ulcers
  • Violaceous, undermined borders
  • Associations: Ulcerative Colitis, autoimmune conditions

🧬 Key Endocrine Findings

🧬 Endocrine System Manifestations

Cushing's Syndrome:

🎯 Characteristic Findings

  • "Moon face" appearance
  • Central obesity with thin limbs
  • Purple abdominal striae
  • Thin, fragile skin with easy bruising

🎯 Etiology

  • Common: Iatrogenic (steroid medications)
  • Endogenous: Pituitary or adrenal tumors

Addison's Disease (Adrenal Insufficiency):

🎯 Cutaneous Findings

  • Diffuse hyperpigmentation
  • Deep tan-like appearance
  • Prominent in palmar creases, scars, buccal mucosa

🎯 Systemic Manifestations

  • Hypotension (orthostatic)
  • Weight loss and wasting
  • Fatigue and weakness

🔄 The Reticuloendothelial System: Lymph Nodes & Blood

🔄 Lymphatic & Haematological Assessment

Lymph Node Palpation Protocol:

🎯 Descriptive Parameters

  • Location: Anatomical region
  • Size: Measurements in centimeters
  • Consistency: Soft, rubbery, hard, firm
  • Tenderness: Pain on palpation
  • Mobility: Fixed vs. mobile

Key Lymph Node Patterns:

🎯 Cervical Nodes

  • Common: Head/neck infections
  • Concerning: Malignancy in older adults (nasopharyngeal cancer)

🎯 Virchow's Node

  • Left supraclavicular location
  • High suspicion: Abdominal malignancy (gastric cancer)

🎯 Generalized Lymphadenopathy

  • Multiple region involvement
  • Causes: HIV, Lymphoma, Leukemia, TB, Sarcoidosis

🎯 Lymphoma Patterns

  • Hodgkin's: Often starts in neck nodes
  • Non-Hodgkin's: Often widespread early

Haematological Disease Clues:

🎯 Leukaemia

  • Pallor (anaemia)
  • Petechiae/purpura (thrombocytopenia)
  • Gum hypertrophy and bleeding
  • Recurrent infections

🎯 Sickle Cell Disease

  • Jaundice (hemolysis)
  • Frontal bossing (marrow expansion)
  • Chronic leg ulcers

🎯 Thalassaemia

  • "Mongoloid" facies (marrow expansion)
  • Massive splenomegaly
  • Growth retardation

📋 The Golden Rule: IPPA Sequence

📋 Systematic Examination Framework

IPPA Sequence:

🎯 I - Inspection

  • Visual assessment first
  • Scars, deformities, movements

🎯 P - Palpation

  • Texture, temperature, masses
  • Apex beat, thrills, tenderness

🎯 P - Percussion

  • Organ borders and density
  • Cardiac dullness, liver span

🎯 A - Auscultation

  • Heart sounds, breath sounds
  • Bruits, bowel sounds

Critical Reminder: Do NOT grab your stethoscope first! The IPPA sequence ensures comprehensive assessment and prevents missed findings.

Cardiovascular Example:

  • Inspection: Scars, chest deformities, heaves
  • Palpation: Apex beat location, thrills
  • Percussion: Heart borders
  • Auscultation: Heart sounds, murmurs

Pro Technique: Always examine from the patient's right side. Develop this habit for consistency and thoroughness in your clinical approach.

🎯 Clinical Synthesis

🎯 Bringing It All Together

General Examination Purpose:

  • Forms initial clinical hypothesis
  • Connects physical signs across systems
  • Guides focused system-by-system examination
  • Reveals the story the body is telling

Systematic Approach Areas:

🎯 Assessment Domains

  • Facial characteristics and expressions
  • Hand findings and nail pathology
  • Oral cavity and mucosal examination
  • Skin manifestations and texture
  • Lymph node patterns and characteristics